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Kulak Burun Bogaz Ihtis Derg. 2010 Jul-Aug;20(4):191-4.

[Efficacy of local heparinoids on preventing edema and ecchymosis after rhinoplasty].

[Article in Turkish]

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  • 1Inönü Universitesi Tip Fakültesi, Malatya, Turkey.



In this study, the effect of local heparinoids on prevention of periorbital edema and ecchymosis due to rhinoplasty was investigated.


Twenty patients (12 males, 8 females, mean age 23.3 years; range 19 to 34 years) who had bilateral osteotomy were randomly administered postoperative local heparinoid on one periorbital region, without performing any care in the other one. One and a half centimeter of heparinoid was applied once a day for nine days. The other periorbital region was used as control group. The heparinoid was applied additionally, 8 mg dexamethasone i.v was administered to all patients 30 minutes before the surgery and 24 hours after the surgery. Photographs of each patient which were taken on postoperative days 1, 3, 5 and 9 were evaluated as double-blind by two observers. Scoring was performed according to edema and ecchymosis scales.


There was no statistical difference with respect to edema and ecchymosis between local heparinoid treated and control eyes.


No hypersensitivity to drugs occurred in any patients. After analysing the scores, we observed that heparanoids administered locally was not effective in preventing periorbital edema and ecchymosis after rhinoplasty (p>0.05).

[PubMed - indexed for MEDLINE]
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