J Biomed Biotechnol. 2010;2010:623687. Epub 2010 Jun 1.

RNA vaccines in cancer treatment.

Bringmann A, Held SA, Heine A, Brossart P.

Source

Department of Oncology and Hematology, University Hospital Bonn, Bonn, Germany.

Abstract

The Cancer Report from the World Health Organization states that in the year 2000 12% of all death cases worldwide were caused by cancer. In the western world, the cancer death rates are often devastating, being at about 25%. This fact stresses the urgency to find effective cures against malignant diseases. New approaches in the treatment of cancer focus on the development of immunotherapies to fight the disease. Besides other methods, the usage of tumor-specific RNA as part of vaccines is investigated lately. RNA, administered alone or used for transfection of dendritic cells, shows several advantages as a vaccine including feasibility, applicability, safeness, and effectiveness when it comes to the generation of immune responses. This review concentrates on results from in vitro experiments and recent trials using RNA vaccines to present an overview about this specific strategy.

PMID:: 20625504; [PubMed - indexed for MEDLINE]
PMCID:: PMC2896711

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Current approaches in dendritic cell generation and future implications for cancer immunotherapy. [Cancer Immunol Immunother. 2007]
Review Current approaches in dendritic cell generation and future implications for cancer immunotherapy.
Tuyaerts S, Aerts JL, Corthals J, Neyns B, Heirman C, Breckpot K, Thielemans K, Bonehill A. Cancer Immunol Immunother. 2007 Oct; 56(10):1513-37. Epub 2007 May 15.
Review Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors. [Cell Res. 2006]
Review Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors.
Xia D, Moyana T, Xiang J. Cell Res. 2006 Mar; 16(3):241-59.
Review RNA transfected dendritic cells as cancer vaccines. [Curr Opin Mol Ther. 2000]
Review RNA transfected dendritic cells as cancer vaccines.
Mitchell DA, Nair SK. Curr Opin Mol Ther. 2000 Apr; 2(2):176-81.
Review Therapeutic cancer vaccines. [Surg Oncol Clin N Am. 2007]
Review Therapeutic cancer vaccines.
Morris LF, Ribas A. Surg Oncol Clin N Am. 2007 Oct; 16(4):819-31, ix.
Review Current state and perspectives of dendritic cell vaccination in cancer immunotherapy. [Skin Pharmacol Physiol. 2006]
Review Current state and perspectives of dendritic cell vaccination in cancer immunotherapy.
Farkas A, Conrad C, Tonel G, Borbenyi Z, Kemeny L, Dobozy A, Nestle FO. Skin Pharmacol Physiol. 2006; 19(3):124-31. Epub 2006 Apr 6.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

RNA vaccines in cancer treatment.
RNA vaccines in cancer treatment.
J Biomed Biotechnol. 2010 ;2010:623687. Epub 2010 Jun 1 .

PubMed
A randomized, double-blind, multicenter, parallel-group, placebo-controlled, dos...
A randomized, double-blind, multicenter, parallel-group, placebo-controlled, dose-optimization study of the methylphenidate transdermal system for the treatment of ADHD in adolescents.
CNS Spectr. 2010 Jul ;15(7):419-30.

PubMed
Early urinary CCL2 is associated with the later development of interstitial fibr...
Early urinary CCL2 is associated with the later development of interstitial fibrosis and tubular atrophy in renal allografts.
Transplantation. 2010 Aug 27 ;90(4):394-400.

PubMed
Anal lymphogranuloma venereum infection screening with IgA anti-Chlamydia tracho...
Anal lymphogranuloma venereum infection screening with IgA anti-Chlamydia trachomatis-specific major outer membrane protein serology.
Sex Transm Dis. 2010 Dec ;37(12):789-95.

PubMed
Markers of cholesterol absorption and synthesis predict the low-density lipoprot...
Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin.
J Cardiovasc Pharmacol. 2010 Oct ;56(4):396-401.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: