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Cancer Res Treat. 2010 Jun;42(2):115-7. doi: 10.4143/crt.2010.42.2.115. Epub 2010 Jun 30.

A case of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma.

Author information

  • 1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. jhcmd@hanyang.ac.kr

Abstract

Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.

KEYWORDS:

Lymphoma; Pure; Red-cell aplasia; T-cell

PMID:
20622966
[PubMed]
PMCID:
PMC2901080
Free PMC Article

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