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Nat Neurosci. 2010 Aug;13(8):923-5. doi: 10.1038/nn.2596. Epub 2010 Jul 11.

Neural substrates of motor memory consolidation depend on practice structure.

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  • 1Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA.


Motor-skill practice drives subsequent offline activity in functionally related resting human brain networks. We investigated the manner in which offline neural networks are modulated by practice structures that affect motor-skill retention. Interference to dorsolateral-prefrontal cortex (DLPFC), but not to primary motor cortex (M1), after variable practice attenuated motor-skill retention, whereas interference to M1, but not to DLPFC, after constant practice attenuated motor-skill retention. We conclude that neural substrates of motor-memory consolidation are modulated by practice structure.

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