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Mol Immunol. 2010 Aug;47(13):2170-5. doi: 10.1016/j.molimm.2010.05.009. Epub 2010 Jun 1.

Complement activation on platelets: implications for vascular inflammation and thrombosis.

Author information

  • 1Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA. ellinor.peerschke@mountsinai.org

Abstract

Platelets participate in a variety of responses of the blood to injury. An emerging body of evidence suggests that these cells express an intrinsic capacity to interact with and trigger both classical and alternative pathways of complement. This activity requires cell activation with biochemical agonists and/or shear stress, and is associated with the expression of P-selectin, gC1qR, and chondroitin sulfate. Platelet mediated complement activation measurably increases soluble inflammatory mediators (C3a and C5a). Platelets may also serve as targets of classical complement activation in autoimmune conditions such as antiphospholipid syndromes (APS) and immune thrombocytopenia purpura (ITP). Retrospective correlation with clinical data suggests that enhanced platelet associated complement activation correlates with increased arterial thrombotic events in patients with lupus erythematosus and APS, and evidence of enhanced platelet clearance from the circulation in patients with ITP. Taken together, these data support a role for platelet mediated complement activation in vascular inflammation and thrombosis.

2010 Elsevier Ltd. All rights reserved.

KEYWORDS:

Platelets; antiphospholipid syndrome; complement; immune thrombocytopenia purpura; inflammation; systemic lupus erythematosus; thrombosis

PMID:
20621693
[PubMed - indexed for MEDLINE]
PMCID:
PMC2904326
Free PMC Article

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