Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Parasitol. 2010 Sep;40(11):1229-35. doi: 10.1016/j.ijpara.2010.05.005. Epub 2010 Jun 8.

Invasion of mosquito salivary glands by malaria parasites: prerequisites and defense strategies.

Author information

  • 1Parasitology Unit, Department of Infectious Diseases, Heidelberg University School of Medicine, 69120 Heidelberg, Germany.

Abstract

The interplay between vector and pathogen is essential for vector-borne disease transmission. Dissecting the molecular basis of refractoriness of some vectors may pave the way to novel disease control mechanisms. A pathogen often needs to overcome several physical barriers, such as the peritrophic matrix, midgut epithelium and salivary glands. Additionally, the arthropod vector elicites immune responses that can severely limit transmission success. One important step in the transmission of most vector-borne diseases is the entry of the disease agent into the salivary glands of its arthropod vector. The salivary glands of blood-feeding arthropods produce a complex mixture of molecules that facilitate blood feeding by inhibition of the host haemostasis, inflammation and immune reactions. Pathogen entry into salivary glands is a receptor-mediated process, which requires molecules on the surface of the pathogen and salivary gland. In most cases, the nature of these molecules remains unknown. Recent advances in our understanding of malaria parasite entry into mosquito salivary glands strongly suggests that specific carbohydrate molecules on the salivary gland surface function as docking receptors for malaria parasites.

Copyright (c) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

PMID:
20621627
[PubMed - indexed for MEDLINE]
PMCID:
PMC2916662
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk