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Trends Biochem Sci. 2010 Dec;35(12):691-8. doi: 10.1016/j.tibs.2010.06.002. Epub 2010 Jul 10.

Molecular architecture of bacterial type IV secretion systems.

Author information

  • 1Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London WC1E 7HX, UK. g.waksman@ucl.ac.uk


In Gram-negative bacteria, type IV secretion (T4S) systems form ATP-powered complexes that span the entire cellular envelope and secrete a wide variety of substrates from single proteins to protein-protein and protein-DNA complexes. Recent structural data, namely the electron microscopy structure of the T4S core complex and the atomic-resolution structure of its outer-membrane pore, have profoundly altered our understanding of T4S architecture and mechanisms.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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