Mol Cell. 2010 Jun 25;38(6):779-80.

A role for SIRT1 in the hypoxic response.

Source

Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Abstract

In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.

Comment on

Mol Cell. 2010 Jun 25;38(6):864-78.

PMID:: 20620950; [PubMed]

Publication Types

Comment

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Related citations

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. [Mol Cell. 2010]
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Mol Cell. 2010 Jun 25; 38(6):864-78.
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. [Acta Biochim Pol. 2006]
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
Bobarykina AY, Minchenko DO, Opentanova IL, Moenner M, Caro J, Esumi H, Minchenko OH. Acta Biochim Pol. 2006; 53(4):789-99. Epub 2006 Dec 4.
Review The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury. [Brain Res Rev. 2009]
Review The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury.
Fan X, Heijnen CJ, van der Kooij MA, Groenendaal F, van Bel F. Brain Res Rev. 2009 Dec 11; 62(1):99-108. Epub 2009 Sep 25.
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. [J Biol Chem. 2007]
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW. J Biol Chem. 2007 Apr 13; 282(15):10873-80. Epub 2007 Feb 15.
Review Sirtuin activators. [Expert Opin Ther Pat. 2009]
Review Sirtuin activators.
Alcaín FJ, Villalba JM. Expert Opin Ther Pat. 2009 Apr; 19(4):403-14.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

A role for SIRT1 in the hypoxic response.
A role for SIRT1 in the hypoxic response.
Mol Cell. 2010 Jun 25 ;38(6):779-80.

PubMed
Genetic variability in progranulin contributes to risk for clinically diagnosed ...
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Neurology. 2008 Aug 26 ;71(9):656-64. Epub 2008 Jun 18 .

PubMed
Effects of androgenic-anabolic steroids in athletes.
Effects of androgenic-anabolic steroids in athletes.
Sports Med. 2004 ;34(8):513-54.

PubMed
Diet and disease--the Israeli paradox: possible dangers of a high omega-6 polyun...
Diet and disease--the Israeli paradox: possible dangers of a high omega-6 polyunsaturated fatty acid diet.
Isr J Med Sci. 1996 Nov ;32(11):1134-43.

PubMed
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms...
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
Cell. 1997 Aug 8 ;90(3):569-80.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

A role for SIRT1 in the hypoxic response.

Source

Abstract

Comment on

Publication Types

Publication Types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information