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AIDS Res Hum Retroviruses. 2010 Jul;26(7):827-32. doi: 10.1089/aid.2009.0311.

Identification of a new HIV type 1 circulating BF intersubtype recombinant form (CRF47_BF) in Spain.

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  • 1Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.


We report the identification of a new HIV-1 circulating recombinant form (CRF47_BF) derived from subtypes B and F. It was initially identified in protease-reverse transcriptase sequences from nine individuals from three separate regions of Spain who acquired HIV-1 infection via sexual contact. All nine sequences formed a strongly supported phylogenetic cluster, branching apart from all known CRFs, and in bootscan analyses were BF mosaics with two coincident breakpoints. Two epidemiologically unlinked viruses were sequenced in near full-length genomes, which exhibited identical mosaic structures, with 16 intersubtype breakpoints in a genome predominantly of subtype B. Subtype F segments of the new CRF failed to cluster with any of the near full-length genome subtype F sequences available in public databases. Recent dates of HIV-1 diagnoses and short genetic distances suggest a recent origin of this CRF. This is the tenth reported CRF_BF, the first apparently having originated outside of South America.

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