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    Org Biomol Chem. 2010 Sep 7;8(17):3857-9. Epub 2010 Jul 8.

    Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives.

    Source

    Department of Chemistry, North Carolina State University, 2620 Yarbrough Dr., Raleigh, NC 27695-8204, USA.

    Abstract

    An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC(50) values.

    PMID:
    20617245
    [PubMed - indexed for MEDLINE]

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