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Front Horm Res. 2010;38:87-93. doi: 10.1159/000318498. Epub 2010 Jul 5.

Serum levels of 20K-hGH and 22K-hGH isoforms in acromegalic patients.

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  • 1Division of Endocrinology, Department of Internal Medicine, Hospital Universit├írio Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. gibalarini@gmail.com


The diagnosis and treatment decisions in acromegaly depend on the measurement of growth hormone (GH) and insulin-like growth factor I (IGF-I) levels. The occurrence of different GH isoforms in the serum, mainly 22K-hGH and 20K-hGH, is a source of heterogeneity of GH results measured by different immunoassays. Since it has been previously reported that the proportion of 20K-hGH is increased in patients with active acromegaly, it might be useful to know the GH isoforms' pattern not to underdiagnose or undertreat acromegalic patients.

Copyright (c) 2010 S. Karger AG, Basel.

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