Clin Transl Oncol. 2010 Jul;12(7):468-72.

Tyrosine kinase inhibitors in treating soft tissue sarcomas: sunitinib in non-GIST sarcomas.

Homet Moreno B, Garralda Cabanas E, Hitt R.

Source

Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Abstract

Sarcomas are uncommon malignancies that represent more than 50 different tumor types. Surgery remains the mainstay of treating localised disease. Anthracycline and ifosfamide-based chemotherapy is an option for advanced disease; however, effective treatment of advanced soft tissue sarcoma remains a challenge. Advances in understanding the genetic nature of cancer have led to the development of new treatment options for sarcoma. Sunitinib malate is an oral multitargeted tyrosine kinase inhibitor with antiangiogenic properties and promising activity in the treatment of GIST refractory to imatinib, however in either soft tissue sarcoma, experience with sunitinib is under development in different clinical trials. In this review we offer the experience with this small molecular target in non-GIST sarcomas.

PMID:: 20615823; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

PYRROLE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review Recent advances in therapy for gastrointestinal stromal tumors. [Curr Oncol Rep. 2007]
Review Recent advances in therapy for gastrointestinal stromal tumors.
Maki RG. Curr Oncol Rep. 2007 May; 9(3):165-9.
[Evidence-based treatment of gastrointestinal stromal tumor (GIST) with tyrosine kinase inhibitors-imatinib and sunitinib]. [Gan To Kagaku Ryoho. 2011]
[Evidence-based treatment of gastrointestinal stromal tumor (GIST) with tyrosine kinase inhibitors-imatinib and sunitinib].
Nishida T, Omori T, Ueshima S. Gan To Kagaku Ryoho. 2011 May; 38(5):733-7.
Review Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor. [Curr Oncol Rep. 2007]
Review Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor.
George S. Curr Oncol Rep. 2007 Jul; 9(4):323-7.
Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib. [Pediatr Blood Cancer. 2009]
Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib.
Janeway KA, Albritton KH, Van Den Abbeele AD, D'Amato GZ, Pedrazzoli P, Siena S, Picus J, Butrynski JE, Schlemmer M, Heinrich MC, et al. Pediatr Blood Cancer. 2009 Jul; 52(7):767-71.
Review Emerging drugs for the treatment of soft tissue sarcomas. [Expert Opin Emerg Drugs. 2007]
Review Emerging drugs for the treatment of soft tissue sarcomas.
Cassier PA, Dufresne A, Fayette J, Alberti L, Ranchere D, Ray-Coquard I, Blay JY. Expert Opin Emerg Drugs. 2007 Mar; 12(1):139-53.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Tyrosine kinase inhibitors in treating soft tissue sarcomas: sunitinib in non-GI...
Tyrosine kinase inhibitors in treating soft tissue sarcomas: sunitinib in non-GIST sarcomas.
Clin Transl Oncol. 2010 Jul ;12(7):468-72.

PubMed
Cerebrospinal fluid estrone in pseudotumor cerebri: a change in cerebral steroid...
Cerebrospinal fluid estrone in pseudotumor cerebri: a change in cerebral steroid hormone metabolism?
J Endocrinol Invest. 1991 Feb ;14(2):81-6.

PubMed
Combined heart-kidney transplant after CardioWest total artificial heart bridge.
Combined heart-kidney transplant after CardioWest total artificial heart bridge.
J Heart Lung Transplant. 2010 Oct ;29(10):1193-5. Epub 2010 Jul 7 .

PubMed
Behavioral complications of drug treatment of Parkinson's disease.
Behavioral complications of drug treatment of Parkinson's disease.
J Am Geriatr Soc. 1991 Jul ;39(7):708-16.

PubMed
[Case-mix index and length of hospitalization].
[Case-mix index and length of hospitalization].
G Chir. 2010 May ;31(5):211-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: