Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Sci (Lond). 2010 Jul 6;119(8):303-11. doi: 10.1042/CS20100201.

Zinc-finger nucleases: new strategies to target the rat genome.

Author information

  • 1Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA. ageurts@mcw.edu

Abstract

The importance of genetic laboratory models, such as mice and rats, becomes evident when there is a poor understanding of the nature of human disease. Many rat models for human disease, created over the years by phenotype-driven strategies, now provide a foundation for the identification of their genetic determinants. These models are especially valuable with the emerging need for validation of genes found in genome-wide association studies for complex diseases. The manipulation of the rat genome using engineered zinc-finger nucleases now introduces a key technology for manipulating the rat genome, which is broadly applicable. The ability to generate knockout rat models using zinc-finger nuclease technology will now enable its full emergence as an exceptional physiological and genetic research model.

PMID:
20615201
[PubMed - indexed for MEDLINE]
PMCID:
PMC3549593
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Portland Press Icon for PubMed Central
    Loading ...
    Write to the Help Desk