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Lik Sprava. 2010 Jan-Mar;(1-2):3-10.

[Pharmacological and pharmaceutical foundation of nanodrugs].

[Article in Ukrainian]


Literary data and results of own investigations about pharmacological and pharmaceutical grounds of nanodrugs are analyzed in the article. Main requirements to nanodrugs are summarized. (1) To have much more expressed effect in comparison with drugs used in a medicinal practice. (2) New nanodrug mustn't have adverse reactions. (3) Nanodrugs must decrease adverse effects of other drugs. (4) Nanodrugs mustn't negatively influence on clinic-pharmacological properties of drugs used in medicinal practice forthe treatment of different disorders. (5) One of the requirements to nanodrugs is positive pharmacoeconomic parameters. (6) Medicinal form of nanodrug must be usable for different ways of drug administration. (7) Technology of drug production should be inexpensive, without negative influence on ecology. Comprehensive experimental researches of nanoparticle pharmacodynamics and pharmacokinetics in the human body and its influence on environment should be done. A new technology of obtaining nanoparticles of iron oxide, silver, copper and their composites has been developed in the laboratory of electron-beam nanotechnology of nonorganic materials for medicine. It was shown, that nanoparticles of iron and silver oxide have more significant antimicrobial activity than oxides of these metals in normal size.

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