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Head Neck Pathol. 2007 Dec;1(2):165-8. doi: 10.1007/s12105-007-0030-5. Epub 2007 Oct 26.

Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue.

Author information

  • 1Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Abstract

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

KEYWORDS:

Adenoid cystic carcinoma; Comparative genomic hybridizations; Cytogenetic; Spectral karyotyping; Translocations

PMID:
20614269
[PubMed - indexed for MEDLINE]
PMCID:
PMC2807514
Free PMC Article

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