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Diabetologia. 2010 Oct;53(10):2134-8. doi: 10.1007/s00125-010-1847-0. Epub 2010 Jul 8.

Childhood cognitive ability: relationship to gestational diabetes mellitus in India.

Author information

  • 1Epidemiology Research Unit, Holdsworth Memorial Hospital, Mandi Mohalla, P.O. Box 38, Mysore 570021, India. veenasr@gmail.com

Abstract

AIMS/HYPOTHESIS:

Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.

METHODS:

During 1997 to 1998 maternal GDM status was assessed by OGTT at 30 +/- 2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children--Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.

RESULTS:

Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p = 0.008), reasoning (p = 0.02), verbal ability (p = 0.01), and attention and concentration (p = 0.003). In multiple regression, adjusted for the child's age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent's socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (beta = 0.4 SD (95% CI 0.01-0.75); p = 0.04) and verbal ability (beta = 0.5 SD (95% CI 0.09-0.83); p = 0.02), and not with other test scores.

CONCLUSIONS/INTERPRETATION:

In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.

PMID:
20614102
[PubMed - indexed for MEDLINE]
PMCID:
PMC3428884
Free PMC Article
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