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    J Chromatogr. 1991 Jan 18;563(1):23-36.

    Determination of free and conjugated normetanephrine and metanephrine in human plasma by high-performance liquid chromatography with electrochemical detection.

    Pagliari R, Cottet-Emard JM, Peyrin L.

    Source

    Université Claude Bernard, Laboratoire de Physiologie, Faculté de Médecine, Lyon, France.

    Abstract

    A simple method for the simultaneous assay of normetanephrine and metanephrine (both free and conjugated) in human plasma by high-performance liquid chromatography with electrochemical detection has been developed. The hydrolysed plasma is purified on a Dowex 50 H+ column, and the methoxylated amines are eluted with ammonia-methanol. The methoxyamines are assayed using a dual-series electrode arrangement with differential current measurement. This system greatly improves the assay specificity toward endogenous or exogenous metabolites and drugs. The high sensitivity of the method enables the determination in normal subjects of levels of normetanephrine and metanephrine.

    PMID:
    2061394
    [PubMed - indexed for MEDLINE]

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