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Curr Opin Infect Dis. 2010 Oct;23(5):403-8. doi: 10.1097/QCO.0b013e32833c3da6.

Advances in Rift Valley fever research: insights for disease prevention.

Author information

  • 1Children's Hospital Oakland Research Institute, Oakland, California, USA. alabeaud@chori.org

Abstract

PURPOSE OF REVIEW:

The purpose was to review recent research on Rift Valley fever virus (RVFV) infection, encompassing four main areas: epidemiology and outbreak prediction, viral pathogenesis, human diagnostics and therapeutics, and vaccine and therapeutic candidates.

RECENT FINDINGS:

RVFV continues to extend its range in Africa and the Middle East. Better definition of RVFV-related clinical syndromes and human risk factors for severe disease, combined with early-warning systems based on remote-sensing, simplified rapid diagnostics, and tele-epidemiology, hold promise for earlier deployment of effective outbreak control measures. Advances in understanding of viral replication pathways and host cell-related pathogenesis suggest means for antiviral therapeutics and for more effective vaccination strategies based on genetically engineered virus strains or subunit vaccines.

SUMMARY:

RVFV is a significant health and economic burden in many areas of Africa, and remains a serious threat to other parts of the world. Development of more effective methods for RVFV outbreak prevention and control remains a global health priority.

PMID:
20613512
[PubMed - indexed for MEDLINE]
PMCID:
PMC3126654
Free PMC Article
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