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Genetics. 2010 Sep;186(1):427-30. doi: 10.1534/genetics.110.119230. Epub 2010 Jul 6.

A strategy for direct mapping and identification of mutations by whole-genome sequencing.

Author information

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de Santé et de Recherche Médicale (INSERM) U964/Centre National de Recherche Scientifique (CNRS) UMR 1704/Université de Strasbourg, 67404 Illkirch CU Strasbourg, France.

Abstract

Mutant screens have proven powerful for genetic dissection of a myriad of biological processes, but subsequent identification and isolation of the causative mutations are usually complex and time consuming. We have made the process easier by establishing a novel strategy that employs whole-genome sequencing to simultaneously map and identify mutations without the need for any prior genetic mapping.

PMID:
20610404
[PubMed - indexed for MEDLINE]
PMCID:
PMC2940307
Free PMC Article

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