Exchange transfusion before cardiopulmonary bypass in sickle cell disease

Ann Thorac Surg. 2010 Jul;90(1):323-4. doi: 10.1016/j.athoracsur.2009.08.037.

Abstract

Cardiac operations in patients with sickle cell disease present the surgical team with many challenges. We describe a method of complete intraoperative exchange transfusion in the operating room that reduces the hemoglobin S (Hb S) level to less than 5%, without preoperative exchange transfusions. Plasma and platelet fractions separated intraoperatively from the patient's native red cell mass were used, in addition to hemoconcentration while on cardiopulmonary bypass, to effectively reduce the red cell and clotting factor transfusion requirements after the procedure. The technique is useful in reducing transfusion requirements, avoiding cardiovascular stress associated with exchange transfusion before the operation, and can be used in urgent situations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Sickle Cell / complications
  • Anemia, Sickle Cell / therapy*
  • Cardiopulmonary Bypass / methods*
  • Exchange Transfusion, Whole Blood / methods*
  • Humans
  • Male
  • Mitral Valve Insufficiency / complications
  • Mitral Valve Insufficiency / surgery*
  • Perioperative Care