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FEBS Lett. 1991 Jun 17;284(1):51-6.

Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria.

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  • 1Max-Planck-Institut für Molekulare Genetik, Abteilung Wittmann, Berlin, Germany.


We have determined the N-termini of 26 proteins of the large ribosomal subunit from yeast mitochondria by direct amino acid micro-sequencing. The N-terminal sequences of proteins YmL33 and YmL38 showed a significant similarity to eubacterial ribosomal (r-) proteins L30 and L14, respectively. In addition, several proteins could be assigned to their corresponding yeast nuclear genes. Based on a comparison of the protein sequences deduced from the corresponding DNA regions with the N-termini of the mature proteins, the putative leader peptides responsible for mitochondrial matrix-targeting were compiled. In most leader sequences a relative abundance of aromatic amino acids, preferentially phenylalanine, was found.

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