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    Trends Mol Med. 2010 Jul;16(7):329-35. Epub 2010 Jun 3.

    Tuberous sclerosis complex: linking cancer to metabolism.

    Mieulet V, Lamb RF.

    Source

    Department of Oncology, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada.

    Abstract

    The TSC1/TSC2 tumor-suppressor complex regulates cell growth via controlling the mTOR (mammalian target of rapamycin) signaling pathway, which contributes to several disease processes, including cancer and diabetes. Abnormal activation of mTOR uncouples anabolic cell growth processes such as protein and lipid synthesis from external growth factor or nutrient cues. However, abnormal activation of mTOR upon loss of TSC1/TSC2 complex function is now known to lead to compensatory mechanisms that restrict the development of malignant tumors. The rare occurrence of complete loss of TSC1/TSC2 function in human tumors suggests that retaining growth suppressor activity might be beneficial during tumour evolution, perhaps by promoting survival when cells grow in a nutrient-limited environment.

    Copyright 2010 Elsevier Ltd. All rights reserved.

    PMID:
    20605525
    [PubMed - indexed for MEDLINE]

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