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J Rehabil Med. 2010 Jul;42(7):679-87. doi: 10.2340/16501977-0581.

Increased interstitial concentrations of pyruvate and lactate in the trapezius muscle of patients with fibromyalgia: a microdialysis study.

Author information

  • 1Rehabilitation Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. Bjorn.Gerdle@liu.se

Abstract

OBJECTIVE:

The aim of this study was to compare the interstitial concentrations of pyruvate, lactate and glutamate in the trapezius muscle between patients with fibromyalgia syndrome and healthy controls.

DESIGN:

Comparative cross-sectional study.

SUBJECTS:

Patients with fibromyalgia (n = 19) and healthy controls (n = 19); all women.

METHODS:

Subjects answered a questionnaire about different aspects of pain. Pressure pain thresholds over the trapezius and tibialis anterior muscles were determined. The inter-stitial concentrations of pyruvate, lactate and glutamate were determined in the resting trapezius muscle by the microdialysis technique, with samples collected every hour for 5 consecutive hours. Pain intensity was also rated.

RESULTS:

Significantly higher interstitial concentrations of pyruvate and lactate were found in patients with fibromyalgia- syndrome. The multivariate regression analyses of group membership and pressure pain thresholds of the trapezius confirmed the importance of pyruvate and lactate.

CONCLUSION:

Different mechanisms that may increase pyruvate and lactate in patients with fibromyalgia syndrome are discussed. Improved understanding of peripheral muscle alterations in patients with fibromyalgia syndrome could lead to mechanism-based rehabilitation.

PMID:
20603699
[PubMed - indexed for MEDLINE]
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