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Parasitology. 2010 Oct;137(12):1773-9. doi: 10.1017/S0031182010000661. Epub 2010 Jul 6.

Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect.

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  • 1Department of Parasitology, Faculty of Science, Charles University in Prague, Viničná 7, CZ-12844 Prague 2, Czech Republic.

Abstract

OBJECTIVE:

RhD-positive subjects are protected against toxoplasmosis-associated impairment of psychomotor performance. Here we searched for RhD-positivity-associated maternal protection against the effects of toxoplasmosis.

METHODS:

In the present retrospective cohort study, we analysed data from 785 (139 RhD-negative) Toxoplasma-free and 194 (27 RhD-negative) Toxoplasma-infected pregnant women. We searched for effects of toxoplasmosis and Rhd-phenotype on maternal weight before pregnancy, pregnancy weight gain, fetal ultrasound data (biparietal diameter, abdominal circumference, femur length) and on birth length and weight.

RESULTS:

At pregnancy week 16, the RhD-negative mothers with toxoplasmosis gained more weight than others (P < 0.001). The difference of about 1600 g remained approximately constant from pregnancy week 16 until the end of pregnancy. Neither toxoplasmosis nor RhD phenotype had any effect on fetal bioparameter data or birth length and weight.

CONCLUSION:

The most parsimonious explanation for the observed data is that the RhD-positive phenotype might protect infected subjects against a broad spectrum of detrimental effects of latent toxoplasmosis, including excessive gestational weight gain.

PMID:
20602855
[PubMed - indexed for MEDLINE]
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