Graphic representation of the candidate genes involved in fluoropyrimidine pharmacodynamics. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/search/pathway/5fu/5fu-pd.jsp. DHF, dihydrofolate; DHFR, dihydrofolate reductase; dTMP, deoxythymidine monophosphate; dUMP, deoxyuridine monophosphate; ERCC, excision repair cross complementing; FdUMP, fluorodeoxyuridine monophosphate; FdUTP, fluoro-deoxyuridine triphosphate; FPGS, folylpolyglutamate synthase; FUTP, fluorouridine triphosphate; GGH, Gammaglutamyl hydrolase; MTHFR, methylenetetrahydrofolate reductase; PK, pharmacokinetics; SMUG1, Single-strand selective monofunctional uracil DNA glycosylase 1; TDG, thymidine DNA glycosylase; THF, 5,10-methylene tetrahydrofolate; TYMS, thymidylate synthase.

Graphic representation of the candidate genes involved in fluoropyrimidine pharmacokinetics. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/do/serve?objId=PA150653776&objCls=Pathway. 5′-dFCR, 5′-deoxy-5-fluorocytidine; 5′-dFUR, 5′-deoxy-5-fluorouridine; 5-FU, 5-fluorouracil; ABCC, ATP-binding cassette, sub-family C; CDA, cytidine deaminase; CES, carboxylesterase; DHFU, dihydrofluorouracil; DPYD, dihydropyrimidine dehydrogenase’; DPYS, dihydropyrimidinease; FBAL, fluoro-β-alanine; FdUDP, fluorodeoxyuridine diphosphate; FdUMP, fluorodeoxyuridine monophosphate; FdUTP, fluoro-deoxyuridine triphosphate; FUDP, fluorouridine diphosphate; FUDR, fluorodeoxyuridine; FUMP, fluorouridine monophosphate; FUPA, fluoro-β-ureidopropionate; FUR, fluroridine; FUTP, fluorouridine triphosphate; PD, pharmacodynamic; PPAT, phosphoribosyl pyrophosphate amidotransferase; RRM, ribonucleotide reductase M; TK1, thymidine kinase 1; Tp53, tumor protein p53; TYMP, thymidylate phosphorylase; TYMS, thymidylate synthase; UCK, uridine-cytidine kinase; UMPS, uridine monophosphate synthase; UPB1, β-ureidopropionase 1; UPP, uridine phosphorylase.