Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroimage. 2010 Dec;53(4):1208-24. doi: 10.1016/j.neuroimage.2010.06.040. Epub 2010 Jun 30.

Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI.

Author information

  • 1Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. pauly2@grasp.upenn.edu

Abstract

We present and evaluate a new method for automatically labeling the subfields of the hippocampal formation in focal 0.4 × 0.5 × 2.0mm(3) resolution T2-weighted magnetic resonance images that can be acquired in the routine clinical setting with under 5 min scan time. The method combines multi-atlas segmentation, similarity-weighted voting, and a novel learning-based bias correction technique to achieve excellent agreement with manual segmentation. Initial partitioning of MRI slices into hippocampal 'head', 'body' and 'tail' slices is the only input required from the user, necessitated by the nature of the underlying segmentation protocol. Dice overlap between manual and automatic segmentation is above 0.87 for the larger subfields, CA1 and dentate gyrus, and is competitive with the best results for whole-hippocampus segmentation in the literature. Intraclass correlation of volume measurements in CA1 and dentate gyrus is above 0.89. Overlap in smaller hippocampal subfields is lower in magnitude (0.54 for CA2, 0.62 for CA3, 0.77 for subiculum and 0.79 for entorhinal cortex) but comparable to overlap between manual segmentations by trained human raters. These results support the feasibility of subfield-specific hippocampal morphometry in clinical studies of memory and neurodegenerative disease.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20600984
[PubMed - indexed for MEDLINE]
PMCID:
PMC2939190
Free PMC Article

Images from this publication.See all images (12)Free text

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk