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Mol Cell Endocrinol. 2011 Mar 1;334(1-2):56-66. doi: 10.1016/j.mce.2010.06.011. Epub 2010 Jun 26.

Nuclear hormone receptors in parasitic helminths.

Author information

  • 1Department of Biochemistry, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA. w_wenjie@hotmail.com

Abstract

Nuclear receptors (NRs) belong to a large protein superfamily that are important transcriptional modulators in metazoans. Parasitic helminths include parasitic worms from the Lophotrochozoa (Platyhelminths) and Ecdysozoa (Nematoda). NRs in parasitic helminths diverged into two different evolutionary lineages. NRs in parasitic Platyhelminths have orthologues in Deuterostomes, in arthropods or both with a feature of extensive gene loss and gene duplication within different gene groups. NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss.

Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
20600585
[PubMed - indexed for MEDLINE]
PMCID:
PMC2974807
Free PMC Article

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