Neurosci Res. 2010 Oct;68(2):151-3. Epub 2010 Jun 22.

Oxytocin mediates the antidepressant effects of mating behavior in male mice.

Matsushita H, Tomizawa K, Okimoto N, Nishiki T, Ohmori I, Matsui H.

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Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

Abstract

A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.

PMID:: 20600375; [PubMed - indexed for MEDLINE]

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