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Head Neck Pathol. 2009 Dec;3(4):327-30. doi: 10.1007/s12105-009-0147-9. Epub 2009 Nov 15.

Tumor-to-tumor metastasis: Renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature.

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  • 1Department of Pathology, MetroHealth Medical Center-Case Western Reserve University, Cleveland, OH 44109, USA.


Metastatic disease to thyroid gland is a rare event. Although renal cell carcinoma (RCC) has been reported to metastasize the thyroid gland, metastatic RCC to a thyroid neoplasm is very unusual. We report a case of a 68-year-old man with history of RCC who presented with a 2.5-cm thyroid nodule. Histologic examination demonstrates a renal cell carcinoma metastatic to a papillary carcinoma of the thyroid. The clinicopathologic features of metastatic disease into a thyroid gland neoplasm are shown, and a review of the literature is presented.

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