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    Am J Trop Med Hyg. 2010 Jul;83(1):152-7.

    Antimicrobial drug resistance trends of bacteremia isolates in a rural hospital in southern Mozambique.

    Mandomando I, Sigaúque B, Morais L, Espasa M, Vallès X, Sacarlal J, Macete E, Aide P, Quintò L, Nhampossa T, Machevo S, Bassat Q, Menéndez C, Ruiz J, Roca A, Alonso PL.

    Source

    Centro de Investigação em Saúde da Manhiça, Vila da Manhiça, Rua 12, PO Box 1929, Maputo, Mozambique. inacio.mandomando@manhica.net

    Abstract

    Antibiotic resistance in Africa is increasing but insufficiently recognized as a public health problem. However, there are scarce data for antimicrobial resistance trends among bloodstream isolates in sub-Saharan Africa. Antimicrobial drug resistance trends among bacteria isolated from blood of children < 15 years of age admitted to the Manhiça District Hospital in Mozambique during May 2001-April 2006 were monitored by disk diffusion. We documented a linear trend of increasing resistance throughout the study period to chloramphenicol among isolates of Non-typhi Salmonella (P < 0.001), Escherichia coli (P = 0.002), Staphylococcus aureus (P < 0.001), and Haemophilus influenzae (P < 0.001). Increasing resistance to ampicillin was also observed for H. influenzae isolates (P < 0.001). We report trends of increasing resistance among the most frequent etiologies of bacteremia to the most commonly used antibiotics for empirical therapy in this community. Quinolones and third-generation cephalosporines may be needed in the short term to manage community-acquired infections.

    PMID:
    20595494
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2912592
    Free PMC Article

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