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Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. doi: 10.1016/j.bmcl.2010.06.049. Epub 2010 Jun 15.

2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

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  • 1Merck Research Laboratories, MSD, Newhouse, Lanarkshire ML1 5SH, UK.


Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors.

Copyright 2010 Elsevier Ltd. All rights reserved.

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