AIDS. 1991 Apr;5(4):431-5.

High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines.

Source

Institut für Pharmazeutische Technologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

Abstract

The aim of the present study was to determine the effect of polymethylmethacrylate (PMMA) nanoparticles as adjuvants for an HIV-2 whole-virus vaccine in mice. The data clearly revealed that PMMA nanoparticles induced 10-100-fold higher antibody titres than aluminium hydroxide or an aqueous vaccine control preparation as measured by enzyme-linked immunosorbent assay. Moreover, the high antibody titres obtained with PMMA as adjuvant appeared to be stable for between 10 and 20 weeks after immunization. In contrast, the titres of the control preparations, fluid or aluminium hydroxide formulations, decreased after 10 weeks.

PMID:: 2059385; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Medical

Molecular Biology Databases

ALUMINUM HYDROXIDE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection. [Vaccine. 2008]
Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection.
Bungener L, Geeraedts F, Ter Veer W, Medema J, Wilschut J, Huckriede A. Vaccine. 2008 May 2; 26(19):2350-9. Epub 2008 Mar 18.
Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations. [Vaccine. 1995]
Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations.
Stieneker F, Kersten G, van Bloois L, Crommelin DJ, Hem SL, Löwer J, Kreuter J. Vaccine. 1995 Jan; 13(1):45-53.
Enhancement of a human immunodeficiency virus env DNA vaccine using a novel polycationic nanoparticle formulation. [Immunol Lett. 2003]
Enhancement of a human immunodeficiency virus env DNA vaccine using a novel polycationic nanoparticle formulation.
Locher CP, Putnam D, Langer R, Witt SA, Ashlock BM, Levy JA. Immunol Lett. 2003 Dec 15; 90(2-3):67-70.
Review Nanoparticles as adjuvants for vaccines. [Pharm Biotechnol. 1995]
Review Nanoparticles as adjuvants for vaccines.
Kreuter J. Pharm Biotechnol. 1995; 6:463-72.
Review Antigenic and immunogenic sites of HIV-2 glycoproteins. [Chem Immunol. 1993]
Review Antigenic and immunogenic sites of HIV-2 glycoproteins.
Chiodi F, Björling E, Samuelsson A, Norrby E. Chem Immunol. 1993; 56:61-77.

See reviews... See all...

Cited by 1 PubMed Central article

Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse. [Mol Ther. 2009]
Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse.
Rimessi P, Sabatelli P, Fabris M, Braghetta P, Bassi E, Spitali P, Vattemi G, Tomelleri G, Mari L, Perrone D, et al. Mol Ther. 2009 May; 17(5):820-7. Epub 2009 Feb 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuva...
High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines.
AIDS. 1991 Apr ;5(4):431-5.

PubMed
Confocal laser scanning microscopy method for quantitative characterization of s...
Confocal laser scanning microscopy method for quantitative characterization of silica monolith morphology.
Anal Chem. 2010 Aug 1 ;82(15):6569-75.

PubMed
Metabolomic profiles and sensory attributes of edamame under various storage dur...
Metabolomic profiles and sensory attributes of edamame under various storage duration and temperature conditions.
J Agric Food Chem. 2010 Jul 28 ;58(14):8418-25.

PubMed
Managing disease on the goldmines: 'work-related' and 'non-work-related' disease...
Managing disease on the goldmines: 'work-related' and 'non-work-related' diseases.
S Afr Med J. 1998 ;88(6 Suppl):789-95.

PubMed
Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastro...
Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract.
World J Gastroenterol. 2010 Jul 7 ;16(25):3112-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information