Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Drug Discov. 2010 Jul;9(7):537-50. doi: 10.1038/nrd3141.

Aptamers as therapeutics.

Author information

  • 1X-Chem Incorporated, 100 Beaver Street,Waltham, Massachusetts 02453, USA.

Erratum in

  • Nat Rev Drug Discov. 2010 Aug;9(8):660.

Abstract

Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to bind a wide range of biomedically relevant proteins with affinities and specificities that are comparable to antibodies. Aptamers exhibit significant advantages relative to protein therapeutics in terms of size, synthetic accessibility and modification by medicinal chemistry. Despite these properties, aptamers have been slow to reach the marketplace, with only one aptamer-based drug receiving approval so far. A series of aptamers currently in development may change how nucleic acid therapeutics are perceived. It is likely that in the future, aptamers will increasingly find use in concert with other therapeutic molecules and modalities.

PMID:
20592747
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk