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Psychiatry Res. 2011 Jan 30;185(1-2):286-9. doi: 10.1016/j.psychres.2010.06.006. Epub 2010 Jun 29.

Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis.

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  • 1Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla-IFIMAV, School of Medicine, University of Cantabria, Santander, Spain.


Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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