Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Acquir Immune Defic Syndr. 2010 Sep;55(1):58-64. doi: 10.1097/QAI.0b013e3181db059d.

Considerations in using US-based laboratory toxicity tables to evaluate laboratory toxicities among healthy malawian and Ugandan infants.

Author information

  • 1Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda. ilubega@mujhu.org

Abstract

OBJECTIVES:

To determine normal hematologic and selected blood chemistry values among healthy, full-term, non-HIV-exposed infants in Uganda and Malawi, and to determine the proportion of healthy babies with an apparent laboratory toxicity based on Division of AIDS toxicity tables.

DESIGN:

This was a cross-sectional laboratory study of infants from birth to 6 months of age.

METHODS:

Blood samples were collected from a total of 561 infants and analyzed according to age categories similar to those in the 2004 Division of AIDS toxicity tables. Select chemistry and hematology parameters were determined and values compared with those in the toxicity tables.

RESULTS:

In the first 56 days of life, there were few graded toxicities except for neutropenia in 2 of 10 (20%) Ugandan and 13 of 45 (29%) Malawian infants at birth. After 7 days, about 20% of the infants in Uganda and Malawi would have been classified as having a neutropenia whereas 47% and 53% of those more than 2 months of age in Uganda and Malawi respectively, would have been reported as having an abnormal hemoglobin. Chemistry findings were not different from US norms.

CONCLUSIONS:

These findings underscore the importance of establishing relevant local laboratory norms for infants.

PMID:
20588184
[PubMed - indexed for MEDLINE]
PMCID:
PMC3033212
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk