Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS Comput Biol. 2010 Jun 17;6(6):e1000817. doi: 10.1371/journal.pcbi.1000817.

Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks.

Author information

  • 1Systems Biology Doctoral Training Centre, University of Oxford, Oxford, United Kingdom.

Abstract

The idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fact be attributed to a tiny subset of them. Crucially, these few, extremely central, hubs do not display particularly low expression correlation, undermining the idea of a link between this quantity and hub function. The date/party distinction was originally motivated by an approximately bimodal distribution of hub co-expression; we show that this feature is not always robust to methodological changes. Additionally, topological properties of hubs do not in general correlate with co-expression. However, we find significant correlations between interaction centrality and the functional similarity of the interacting proteins. We suggest that thinking in terms of a date/party dichotomy for hubs in protein interaction networks is not meaningful, and it might be more useful to conceive of roles for protein-protein interactions rather than for individual proteins.

PMID:
20585543
[PubMed - indexed for MEDLINE]
PMCID:
PMC2887459
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk