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Antimicrob Agents Chemother. 2010 Sep;54(9):3985-7. doi: 10.1128/AAC.01799-09. Epub 2010 Jun 28.

Serum and cerebrospinal fluid levels of colistin in pediatric patients.

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  • 13rd Department of Pediatrics, Aristotle University, Thessaloniki, Greece.


Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 1 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 microg/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 microg/ml but increased in the presence of meningitis (approximately 0.5 microg/ml or 34 to 67% of serum levels).

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