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Ann Neurol. 2010 Jul;68(1):6-8. doi: 10.1002/ana.22057.

Multiple sclerosis and viruses.

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  • Department of Microbiology Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA. mbrahic@stanford.edu


Discussing the problem of multiple sclerosis and viruses should not be limited to reviewing the epidemiological evidence in favor, or against, a particular candidate, such as Epstein-Barr virus or human herpes virus 6. In this text, I discuss the difficulty of going from association to causation in human epidemiology; the fact that viruses can trigger or prevent autoimmunity; the problem of our very limited knowledge of the viruses that we harbor as part of our metagenome; and the role of such viral flora in multifactorial diseases and also, possibly, in health.

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