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    J Therm Anal Calorim. 2009 Mar 20;95(3):721-725.

    EFFECT OF PHALLOIDIN ON FILAMENTS POLYMERIZED FROM HEART MUSCLE ADP-ACTIN MONOMERS.

    Vig A, Dudás R, Kupi T, Orbán J, Hild G, Lőrinczy D, Nyitrai M.

    Source

    University of Pécs, Faculty of Medicine, Department of Biophysics, Szigeti str. 12, Pécs 7624, Hungary.

    Abstract

    The effect of phalloidin on filaments polymerized from ADP-actin monomers of the heart muscle was investigated with differential scanning calorimetry. Heart muscle contains alpha-skeletal and alpha-cardiac actin isoforms. In the absence of phalloidin the melting temperature was 55 degrees C for the alpha-cardiac actin isoform and 58 degrees C for the alpha-skeletal one when the filaments were generated from ADP-actin monomers. After the binding of phalloidin the melting temperature was isoform independent (85.5 degrees C). We concluded that phalloidin stabilized the actin filaments of alpha-skeletal and alpha-cardiac actin isoforms to the same extent when they were polymerized from ADP-actin monomers.

    PMID:
    20582250
    [PubMed]
    PMCID:
    PMC2892334
    Free PMC Article

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