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Nat Genet. 2010 Jul;42(7):558-60. doi: 10.1038/ng0710-558.

Hints of hidden heritability in GWAS.

Abstract

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

PMID:
20581876
[PubMed - indexed for MEDLINE]
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