J Child Neurol. 2010 Sep;25(9):1116-29. Epub 2010 Jun 25.

Change in natural history of Duchenne muscular dystrophy with long-term corticosteroid treatment: implications for management.

Moxley RT 3rd, Pandya S, Ciafaloni E, Fox DJ, Campbell K.

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Department of Neurology, University of Rochester, Rochester, NY 14642, USA. tracy_forrester@urmc.rochester.edu

Abstract

In 2005, the American Academy of Neurology and the Child Neurology Society published a practice parameter, based primarily on studies that involved 6 to 18 months of treatment, indicating that prednisone has a beneficial effect on muscle strength and function in patients with Duchenne muscular dystrophy and recommended that corticosteroids be offered (prednisone 0.75 mg/kg/d and deflazacort 0.9 mg/kg/d) as treatment. Recent reports emphasize that longer term treatment with corticosteroids (greater than 3 years) produces important sustained benefits in neuromuscular function without causing major side effects. This review highlights these reports and indicates that long-term corticosteroid therapy (1) prolongs ambulation by 2 to 5 years, (2) reduces the need for spinal stabilization surgery, (3) improves cardiopulmonary function, (4) delays the need for noninvasive nasal ventilation, and (5) increases survival and the quality of life of patients with Duchenne muscular dystrophy. Educational, vocational, and other social counseling is now a vital part of management for Duchenne muscular dystrophy.

PMID:: 20581335; [PubMed - indexed for MEDLINE]

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deflazacort

MW: 441.51 g/mol

MF: C₂₅H₃₁NO₆

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Change in natural history of Duchenne muscular dystrophy with long-term corticosteroid treatment: implications for management.

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