Southeast Asian J Trop Med Public Health. 2010 May;41(3):514-6.

Vitamin K injection in spontaneous bleeding and coagulopathy in severe malaria: pros and cons.

Wilairatana P, Krudsood S, Tangpukdee N.

Source

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand. tmpwl@mahidol.ac.th

Abstract

Not all clinicians give vitamin K to severe malaria patients with systemic bleeding. Vitamin K injections may not be useful to stop bleeding in severe malaria patients with predominant hepatocellular jaundice. However, vitamin K may be justified in bleeding patients who have prolonged fasting of more than 3-7 days, underlying malnutrition, or predominant cholestatic jaundice. The decision to give vitamin K to severe malaria patients with systemic bleeding should be based on underlying diseases, type of jaundice, risk for vitamin K deficiency, and allergy to the drug.

PMID:: 20578536; [PubMed - indexed for MEDLINE]

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