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Planta Med. 2010 Nov;76(16):1892-6. doi: 10.1055/s-0030-1250029. Epub 2010 Jun 24.

Isolation and anti-inflammatory activity evaluation of triterpenoids and a monoterpenoid glycoside from Harpagophytum procumbens.

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  • 1Key Laboratory of Modern TCM Department of Pharmacognosy, China Pharmaceutical University, Nanjing, P R China.

Abstract

A new triterpenoid glycoside, designated harproside (1), and a new iridoid glycoside, named pagide (2), along with six known triterpenoids (3-8), were obtained from the tubers of Harpagophytum procumbens D. C. (devil's claw), and their structures were established through chemical methods and spectroscopic analyses. In an in vitro assay, the six triterpenoids showed anti-inflammatory activity. Compounds 3, 7, and 8 showed significant inhibitory activity against neutrophil respiratory burst stimulated by PMA, while compounds 4, 5, and 6 showed marginal inhibitory activity.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID:
20577946
[PubMed - indexed for MEDLINE]
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