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J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):380-7. doi: 10.1002/jbm.b.31664.

Composite nanofiber mats consisting of hydroxyapatite and titania for biomedical applications.

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  • 1Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, South Korea.

Abstract

Composite nanofiber mats (HA/TiO2) consisting of hydroxyapatite (HA) and titania (TiO2) were fabricated via an electrospinning technique and then collagen (type I) was immobilized on the surface of the HA/TiO2 composite nanofiber mat to improve tissue compatibility. The structure and morphology of the collagen-immobilized composite nanofiber mat (HA/TiO2-col) was investigated using an X-ray diffractometer, electron spectroscopy for chemical analysis, and scanning electron microscope. The potential of the HA/TiO2-col composite nanofiber mat for use as a bone scaffold was assessed by an experiment with osteoblastic cells (MC3T3-E1) in terms of cell adhesion, proliferation, and differentiation. The results showed that the HA/TiO2-col composite nanofiber mats possess better cell adhesion and significantly higher proliferation and differentiation than untreated HA/TiO2 composite nanofiber mats. This result suggests that the HA/TiO2-col composite nanofiber mat has a high-potential for use in the field of bone regeneration and tissue engineering.

PMID:
20574975
[PubMed - indexed for MEDLINE]
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