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    J Physiol Sci. 2010 Sep;60(5):325-30. Epub 2010 Jun 24.

    Association between the angiotensin I-converting enzyme gene insertion/deletion polymorphism and endurance running speed in Japanese runners.

    Tobina T, Michishita R, Yamasawa F, Zhang B, Sasaki H, Tanaka H, Saku K, Kiyonaga A.

    Source

    Graduate School of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 810-0180, Japan. tobitaku@ck9.so-net.ne.jp

    Abstract

    We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and endurance running performance in Japanese elite runners, including several Olympic athletes. The frequency of the I/I genotype was not significantly higher and the frequency of the D/D genotype was not significantly lower in elite runners compared with non-athletes. However, the frequency of the I/D genotype tended to be lower in elite runners than in non-athletes. The best performance was significantly higher for runners with the D/D genotype than for those with the I/I genotype, and the average running speed was significantly higher for those with the combined D/D + I/D genotypes than for those with the I/I genotype. There were no I/I genotypes among the five fastest marathon runners. These results suggest that the D allele of the ACE gene I/D polymorphism is associated with a high level of human endurance.

    PMID:
    20574690
    [PubMed - indexed for MEDLINE]

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