Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Endocrinology. 2010 Sep;151(9):4109-15. doi: 10.1210/en.2010-0336. Epub 2010 Jun 23.

Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.

Author information

  • 1Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98109, USA.

Abstract

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity.

PMID:
20573720
[PubMed - indexed for MEDLINE]
PMCID:
PMC2940486
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk