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Arch Virol. 2010 Sep;155(9):1453-61. doi: 10.1007/s00705-010-0728-7. Epub 2010 Jun 23.

Dengue-2-virus-interacting polypeptides involved in mosquito cell infection.

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  • 1Molecular Biology Research Laboratory, Department of Zoology, Centre for Advance Studies, University of Pune, Pune, India.


For the design of effective antiviral strategies, understanding the fundamental steps of the virus life cycle, including virus-host interactions, is essential. We performed a virus overlay protein binding assay followed by proteomics for identification of proteins from membrane fractions of A7 (Aedes aegypti) cells, C6/36 (Aedes albopictus) cells and the midgut brush border membrane fraction of Ae. aegypti mosquito that bind to dengue-2 virus. Actin, ATP synthase β subunit, HSc 70, orisis, prohibitin, tubulin β chain, and vav-1 were identified as dengue-2-virus-binding proteins. Our results suggest that dengue-2 virus exploits an array of housekeeping proteins for its entry in mosquito cells.

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