Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biol Psychiatry. 2010 Sep 1;68(5):425-32. doi: 10.1016/j.biopsych.2010.04.020. Epub 2010 Jun 8.

Volitional control of anterior insula activity modulates the response to aversive stimuli. A real-time functional magnetic resonance imaging study.

Author information

  • 1Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University of Tübingen, Tübingen, Germany. andrea.caria@uni-tuebingen.de

Abstract

BACKGROUND:

A promising new approach to cognitive neuroscience based on real-time functional magnetic resonance imaging (rtfMRI) demonstrated that the learned regulation of the neurophysiological activity in circumscribed brain regions can be used as an independent variable to observe its effects on behavior. Here, for the first time, we investigated the modulatory effect of learned regulation of blood oxygenation level-dependent (BOLD) response in the left anterior insula on the perception of visual emotional stimuli.

METHODS:

Three groups of participants (n = 27) were tested: two underwent four rtfMRI training sessions receiving either specific (n = 9) or unspecific feedback (n = 9) of the insula's BOLD response, respectively, and one group used emotional imagery alone (n = 9) without rtfMRI feedback. During training, all groups were required to assess aversive and neutral pictures.

RESULTS:

Participants able to significantly increase BOLD signal in the target region rated the aversive pictures more negatively. We measured a significant correlation between enhanced left anterior insula activity and increased negative valence ratings of the aversive stimuli. Control groups performing either rtfMRI training with unspecific feedback or an emotional imagery training alone were not able to significantly enhance activity in the left anterior insula and did not show changes in subjective emotional responses.

CONCLUSIONS:

This study corroborates traditional neuroimaging studies demonstrating a critical role of the anterior insula in the explicit appraisal of emotional stimuli and indicates the adopted approach as a potential tool for clinical applications in emotional disorders.

Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PMID:
20570245
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk