Mutagenesis. 1991 Mar;6(2):165-7.

Interpretation of results with the 8-azaguanine resistance system in Salmonella typhimurium: no evidence for direct acting mutagenesis by 15-oxosteviol, a possible metabolite of steviol.

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School of Molecular Sciences, University of Sussex, Falmer, Brighton, UK.

Abstract

15-Oxosteviol, postulated to be the mutagenic metabolite of steviol, was observed to be non-mutagenic in preliminary experiments using a number of different systems. Repetition of the original experiment in Salmonella TM677 failed to show any significant induction of 8-azaguanine resistant mutants by 15-oxosteviol even when the number of bacteria tested was greatly increased. Examination of the earlier positive result showed that it could not be justified from the data and revealed a commonly applied way of mishandling data obtained with the TM677 system.

PMID:: 2056919; [PubMed - indexed for MEDLINE]

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[Mutagenicity of steviol: an analytical approach using the Southern blotting system]. [Eisei Shikenjo Hokoku. 1989]
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Interpretation of results with the 8-azaguanine resistance system in Salmonella typhimurium: no evidence for direct acting mutagenesis by 15-oxosteviol, a possible metabolite of steviol.
Mutagenesis. 1991 Mar ;6(2):165-7.

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