Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Microbiol. 2010 Aug;13(4):491-500. doi: 10.1016/j.mib.2010.05.016. Epub 2010 Jun 21.

The flagellum in malarial parasites.

Author information

  • 1The Malaria Centre, The Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom. r.sinden@imperial.ac.uk

Abstract

The malarial parasites assemble flagella exclusively during the formation of the male gamete in the midgut of the female mosquito vector. The observation of gamete formation ex vivo reported by Laveran (Laveran MA: De la nature parasitaire des accidents de l'impaludisme. Comptes Rendues De La Societe de Biologie. Paris 1881, 93:627-630) was seminal to the discovery of the parasite itself. Following ingestion of malaria-infected blood by the mosquito, microgamete formation from the terminally arrested gametocytes is exceptionally rapid, completing three mitotic divisions in just a few minutes, and is precisely regulated. This review attempts to draw together the diverse original observations with subsequent electron microscopic studies, and recent work on the signalling pathways regulating sexual development, together with transcriptomic and proteomic studies that are paving the way to new understandings of the molecular mechanisms involved and the potential they offer for effective interventions to block the transmission of the parasites in natural communities.

Copyright 2010 Elsevier Ltd. All rights reserved.

Comment in

PMID:
20566299
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk